The Clinicopathological Factors Associated with Disease Progression in Luminal A Breast Cancer and Characteristics of Metastasis: A Retrospective Study from A Single Center in China.
نویسندگان
چکیده
BACKGROUND/AIM This study investigated the clinicopathological factors associated with outcomes in patients with Luminal A breast cancer. PATIENTS AND METHODS Retrospective analysis of the association of clinicopathological factors and breast cancer outcome in 421 patients with newly-diagnosed Luminal-A breast cancer that were enrolled from January 2008 to December 2014. Clinicopathological data were analyzed to validate the relationship with disease-free survival (DFS) and overall survival (OS). Kaplan-Meier curves and log-rank tests were used to analyze the value of clinicopathological factors (tumor size, node status and lymphovascular invasion), and subsequent Cox regression analysis revealed significant prognostic factors. RESULTS With a median of 61 months follow-up, the 5-year DFS and 5-year OS rate were 98.3% and 99.3%. Cox multivariate regression analysis showed that clinical anatomic stage, tumor size, status of lymph nodes, lymphovascular invasion and systemic treatment are strong prognostic factors for clinical outcome in patients with Luminal-A breast cancer. Of all 413 patients with stage I-III breast cancer, 14 presented with metastasis (3.4%) during the follow up. Bone (6/14, 42.9%) was the most common site of metastasis followed by liver (5/14, 35.7%) and lung (4/14, 28.6%). The median survival time after metastasis was 20.4 months. Of all the sites of distant metastasis, liver metastasis was the only factor that affected survival time after metastasis (χ2=6.263, p=0.012). CONCLUSION Patients with Luminal A breast cancer have excellent outcomes. Liver metastasis is an important factor compressing the survival time after distant metastasis presents.
منابع مشابه
Immunohistochemical Expression of Nanog and Its Relation with Clinicopathologic Characteristics in Breast Ductal Carcinoma
Background: Cancer stem cells (CSCs) are a group of tumor cells with self-renewal property and differentiation potential. CSCs play a crucial role in malignant progression of several types of tumors. However, what is still controversial is the clinicopathological relationship between Nanog marker and its prognostic value in the patients with breast cancer. The expression of Nanog in the patient...
متن کاملPotential role of hsa_circ_0003098 circular RNA in breast cancer and its association with demographic factors and lymph node metastasis
Background and Objectives: A growing amount of evidence has revealed that circular RNAs (circRNAs), covalently closed single-stranded non-coding RNAs (ncRNAs), play significant roles in initiation and progression of breast cancer (BC) through different mechanisms. This study aims to investigate the hsa_circ_0003098 expression and its potential roles in BC, as well as the circRNA/miRNA/mRNA cro...
متن کاملAnalyzing the Survival of Patients with Breast Cancer with a Multistate Model
Introduction: Breast cancer is the second most common cancer and one of the most common causes of death in women. Metastasis is also a challenge for breast cancer patients, affecting their survival. This study aimed to determine the survival rate and measure the factors affecting the progression of the disease from the time of diagnosis by considering metastasis as an intermediate condition usi...
متن کاملClinicopatholgic Parameters Associated With Regional Lymph Node Metastasis In Oral Squamous Cell Carcinoma: A Retrospective Study
Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph ...
متن کاملAssociation Between Oncotype DX Recurrence Score and Clinicopathological Variables in Breast Cancer Patients
Introduction: Breast cancer is the most common cancer and the leading cause of cancer-related death in women. Clinicopathological variables are important factors in deciding on breast cancer treatment. This study evaluated the association between the recurrence score generated by the Oncotype DX® 21-gene assay and classic clinicopathological variables. Methods: A single-institution retrospect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Anticancer research
دوره 37 8 شماره
صفحات -
تاریخ انتشار 2017